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doi:10.1016/j.tips.2005.06.006

In aged type 2 diabetes complicated with acute brain infarction (tissue death from blood clots), lipoic acid significantly reduced the patients oxidative stress, blood glucose and cholesterol levels [30]

Adjust dose based on response and tolerance

Studies with NR supplementation in PD or HF patients have provided indications of impacting mitochondrial function in peripheral tissues, although evidence for impacting mitochondria in the primary target tissues was not reported 318,319